Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications
- Han, J
- Schmidt, A
- Zhang, T
- Permentier, H
- Groothuis, G M M
- Bischoff, R
- Kühn, F E
- Horvatovich, P
- Casini, A
DOIAbstract
Supramolecular Pd2L4 cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd2L4 cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.</p
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