Add to ORKGDietary heme and calcium are alleged modulators of colon cancer risk. Little is known about the molecular and cellular changes in the colon epithelium that are induced by consumption of these unabsorbed nutrients. In this nutrigenomics study, we fed rats high- and low-calcium diets with or without heme. In agreement with previous studies, we found that dietary heme increased the cytotoxicity of fecal water in the colon and elevated epithelial proliferation, a risk factor in colon carcinogenesis. Calcium reduced cytotoxicity and inhibits heme-induced effects. Among 365 colon-expressed genes, we could identify 10 diet-modulated genes that show >2-fold altered expression, of which several are related to colon cell turnover and disease. Muco...
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, i...
Red meat intake is associated with increased risk of colorectal cancer. We have previously shownthat...
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, i...
Dietary heme and calcium are alleged modulators of colon cancer risk. Little is known about the mole...
Consumption of red meat is associated with increased colon cancer risk. Our previous work indicated ...
Epidemiological and animal model studies suggest that a high intake of heme, present in red meat, is...
High intake of red meat is associated with increased colon cancer risk. We have shown earlier that t...
High intake of red meat is associated with increased colon cancer risk. We have shown earlier that t...
The intake of a Western diet with a high amount of red meat is associated with a high risk for colon...
The intake of a Western diet with a high amount of red meat is associated with a high risk for colon...
Item does not contain fulltextMucosal pentraxin (Mptx), identified in rats, is a short pentraxin of ...
Colorectal cancer is a leading cause of cancer deaths in Western countries. The risk to develop colo...
Mucosal pentraxin (Mptx), identified in rats, is a short pentraxin of unknown function. Other subfam...
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, i...
Red meat intake is associated with increased risk of colorectal cancer. We have previously shownthat...
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, i...
Dietary heme and calcium are alleged modulators of colon cancer risk. Little is known about the mole...
Consumption of red meat is associated with increased colon cancer risk. Our previous work indicated ...
Epidemiological and animal model studies suggest that a high intake of heme, present in red meat, is...
High intake of red meat is associated with increased colon cancer risk. We have shown earlier that t...
High intake of red meat is associated with increased colon cancer risk. We have shown earlier that t...
The intake of a Western diet with a high amount of red meat is associated with a high risk for colon...
The intake of a Western diet with a high amount of red meat is associated with a high risk for colon...
Item does not contain fulltextMucosal pentraxin (Mptx), identified in rats, is a short pentraxin of ...
Colorectal cancer is a leading cause of cancer deaths in Western countries. The risk to develop colo...
Mucosal pentraxin (Mptx), identified in rats, is a short pentraxin of unknown function. Other subfam...
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, i...
Red meat intake is associated with increased risk of colorectal cancer. We have previously shownthat...
Red meat consumption is associated with an increased colon cancer risk. Heme, present in red meat, i...