The anti-aging gene klotho plays an important role in Ca2+ and phosphate homeostasis. Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can be cleaved by proteases, including a disintegrin and metalloproteinase (ADAM) 10 and ADAM17. Cleavage of klotho occurs at a site directly above the plasma membrane (alpha-cut) or between the KL1 and KL2 domain (beta-cut), resulting in soluble full-length klotho or KL1 and KL2 fragments, respectively. The aim of the present study was to gain insights into the mechanisms behind klotho cleavage processes in the kidney. Klotho shedding was demonstrated using a Madin-Darby canine kidney cell line stably expressing klotho and human embryonic kidney-293 cells transiently tran...
The klotho gene encodes a type I single-pass transmembrane protein that contains a large extracellul...
43. Asai O, Nakatani K, Tanaka T et al. Decreased renal alpha-Klotho expression in early diabetic ne...
Klotho gene was identified in 1997, and named after a Greek goddess Klotho, who spun the thread of l...
The anti-aging gene klotho plays an important role in Ca2+ and phosphate homeostasis. Membrane-bound...
The anti-aging gene klotho plays an important role in Ca(2+) and phosphate homeostasis. Membrane-bou...
alpha-Klotho (Klotho) exists in two different forms, a membrane-bound and soluble form, which are hi...
A defect in Klotho gene expression in the mouse results in a syndrome that resembles rapid human agi...
Klotho is a renal protein involved in phosphate homeostasis, which is down-regulated in renal diseas...
A defect in Klotho gene expression in the mouse results in a syndrome that resembles rapid human agi...
Defects in klotho gene expression in the mouse result in a syndrome that resembles human aging. Howe...
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choro...
Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients underg...
Calcium and phosphorous are critical elements in a number of physiological processes, including mai...
Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts as a permiss...
αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast Growth Factor-23, w...
The klotho gene encodes a type I single-pass transmembrane protein that contains a large extracellul...
43. Asai O, Nakatani K, Tanaka T et al. Decreased renal alpha-Klotho expression in early diabetic ne...
Klotho gene was identified in 1997, and named after a Greek goddess Klotho, who spun the thread of l...
The anti-aging gene klotho plays an important role in Ca2+ and phosphate homeostasis. Membrane-bound...
The anti-aging gene klotho plays an important role in Ca(2+) and phosphate homeostasis. Membrane-bou...
alpha-Klotho (Klotho) exists in two different forms, a membrane-bound and soluble form, which are hi...
A defect in Klotho gene expression in the mouse results in a syndrome that resembles rapid human agi...
Klotho is a renal protein involved in phosphate homeostasis, which is down-regulated in renal diseas...
A defect in Klotho gene expression in the mouse results in a syndrome that resembles rapid human agi...
Defects in klotho gene expression in the mouse result in a syndrome that resembles human aging. Howe...
Klotho is an anti-aging protein predominantly expressed in the kidney, parathyroid glands, and choro...
Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients underg...
Calcium and phosphorous are critical elements in a number of physiological processes, including mai...
Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts as a permiss...
αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast Growth Factor-23, w...
The klotho gene encodes a type I single-pass transmembrane protein that contains a large extracellul...
43. Asai O, Nakatani K, Tanaka T et al. Decreased renal alpha-Klotho expression in early diabetic ne...
Klotho gene was identified in 1997, and named after a Greek goddess Klotho, who spun the thread of l...