Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults
- Zimmermann, E.
- Angquist, L. H.
- Mirza, S. S.
- Zhao, J. H.
- Chasman, D. I.
- Fischer, K.
- Qi, Q.
- Smith, A. V.
- Thinggaard, M.
- Jarczok, M. N.
- Nalls, M. A.
- Trompet, S.
- Timpson, N. J.
- Schmidt, B.
- Jackson, A. U.
- Lyytikainen, L. P.
- Verweij, N.
- Mueller-Nurasyid, M.
- Vikstrom, M.
- Marques-Vidal, P.
- Wong, A.
- Meidtner, K.
- Middelberg, R. P.
- Strawbridge, R. J.
- Christiansen, L.
- Kyvik, K. O.
- Hamsten, A.
- Jaaskelainen, T.
- Tjonneland, A.
- Eriksson, J. G.
- Whitfield, J. B.
- Boeing, H.
- Hardy, R.
- Vollenweider, P.
- Leander, K.
- Peters, A.
- van der Harst, P.
- Kumari, M.
- Lehtimaki, T.
- Meirhaeghe, A.
- Tuomilehto, J.
- Joeckel, K. -H.
- Ben-Shlomo, Y.
- Sattar, N.
- Baumeister, S. E.
- Smith, G. Davey
- Casas, J. P.
- Houston, D. K.
- Maerz, W.
- Christensen, K.
Publication date
April 2015
DOIAbstract
Previously, a single nucleotide polymorphism (SNP), rs9939609, in the FTO gene showed a much stronger association with all-cause mortality than expected from its association with body mass index (BMI), body fat mass index (FMI) and waist circumference (WC). This finding implies that the SNP has strong pleiotropic effects on adiposity and adiposity-independent pathological pathways that leads to increased mortality. To investigate this further, we conducted a meta-analysis of similar data from 34 longitudinal studies including 169,551 adult Caucasians among whom 27,100 died during follow-up. Linear regression showed that the minor allele of the FTO SNP was associated with greater BMI (n=169,551; 0.32kgm(-2); 95% CI 0.28-0.32, P</p
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