Add to ORKGThe effects of the cholinesterase inhibitors (ChEI) metrifonate and donepezil were assessed on spatial performance of rats with bilateral lesions of the entorhinal cortex (EC), which is thought to model early changes in the brains of patients suffering from Alzheimer's disease. In the present study, we found that spatial discrimination deficits in rats, induced by bilateral ibotenic acid (IBO) lesions of the EC region can partially be antagonised by treatment with the cholinesterase inhibitors metrifonate (30 mg kg-1) and donepezil (0.3 and 3 mg kg-1). Performance was improved in the spatial discrimination task compared with that of the EC-lesioned control group. It is concluded that the rat with bilateral EC lesions is a suitable deficit m...
The purpose of the present experiments was to study the effects of a combined cholinergic and seroto...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
Spatial discrimination of ibotenic acid-lesioned C57BL/6 (B6) and DBA/2 (D2) mice was tested in two-...
The effects of the cholinesterase inhibitors (ChEI) metrifonate and donepezil were assessed on spati...
The aim of these experiments was to assess whether the clinically validated cognition enhancers done...
The aim of these experiments was to assess whether the clinically validated cognition enhancers done...
Lesions of the nucleus basalis magnocellularis (nbm) in the rat result in cholinergic and cognitive ...
Excitotoxic lesions of the basal forebrain were made by infusing either α-amino-3-hydroxy-5-methyl-4...
The studies concentrated on spatial orientation are very popular in these days. Based on its results...
Background and Objective: Dysfunction and loss of basal forebrain cholinergic neurons and their cort...
The primary visual cortex of rats is surrounded laterally (in Oc2L) and medially (in Oc2M) by severa...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
The role of forebrain cholinergic projections in place navigation learning was assessed in two exper...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
The purpose of the present experiments was to study the effects of a combined cholinergic and seroto...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
Spatial discrimination of ibotenic acid-lesioned C57BL/6 (B6) and DBA/2 (D2) mice was tested in two-...
The effects of the cholinesterase inhibitors (ChEI) metrifonate and donepezil were assessed on spati...
The aim of these experiments was to assess whether the clinically validated cognition enhancers done...
The aim of these experiments was to assess whether the clinically validated cognition enhancers done...
Lesions of the nucleus basalis magnocellularis (nbm) in the rat result in cholinergic and cognitive ...
Excitotoxic lesions of the basal forebrain were made by infusing either α-amino-3-hydroxy-5-methyl-4...
The studies concentrated on spatial orientation are very popular in these days. Based on its results...
Background and Objective: Dysfunction and loss of basal forebrain cholinergic neurons and their cort...
The primary visual cortex of rats is surrounded laterally (in Oc2L) and medially (in Oc2M) by severa...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
The role of forebrain cholinergic projections in place navigation learning was assessed in two exper...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
The purpose of the present experiments was to study the effects of a combined cholinergic and seroto...
Despite the connections of the retrosplenial cortex strongly suggesting a role in spatial memory, th...
Spatial discrimination of ibotenic acid-lesioned C57BL/6 (B6) and DBA/2 (D2) mice was tested in two-...