microRNAs in hematopoiesis
- Lazare, Seka S.
- Wojtowicz, Edyta E.
- Bystrykh, Leonid V.
- de Haan, Gerald
Publication date
December 2014
DOIAbstract
miRNAs have been implicated in all stages of hematopoiesis including maintenance of self-renewal of hematopoietic stem cells (HSCs) and differentiation into mature blood cells. Regulation by miRNAs is markedly intertwined with transcription factors. In this review, we highlight miRNAs shown to be important for HSC maintenance and lineage differentiation with focus on their interaction with transcription factors. We also pay attention to the diverse modes of miRNA regulation. (C) 2014 Elsevier Inc. All rights reserved.</p
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