We report on the mechanism of membrane fusion mediated by polyethylene glycol (PEG) and Ca2+ by means of a coarse-grained molecular dynamics simulation approach. Our data provide a detailed view on the role of cations and polymer in modulating the interaction between negatively charged apposed membranes. The PEG chains cause a reduction of the inter-lamellar distance and cause an increase in concentration of divalent cations. When thermally driven fluctuations bring the membranes at close contact, a switch from cis to trans Ca2+-lipid complexes stabilizes a focal contact acting as a nucleation site for further expansion of the adhesion region. Flipping of lipid tails induces subsequent stalk formation. Together, our results provide a molecu...
AbstractMembrane fusion is a key event in vesicular trafficking in every cell, and many fusion-relat...
Membrane fusion, essential to eukaryotic life, is broadly envisioned as a three-step process proceed...
In this review, we describe the recent contribution of computer simulation approaches to unravel the...
We report on the mechanism of membrane fusion mediated by polyethylene glycol (PEG) and Ca2+ by mean...
The researches performed in this dissertation is aimed to solve the role of calcium in the membrane ...
The effect of viscosity on the encounter rate of two interacting membranes was investigated by combi...
This project is focused on understanding the role of calcium in membrane fusion at the atomic level....
AbstractAlthough membrane fusion plays key roles in intracellular trafficking, neurotransmitter rele...
PEG-mediated fusion of SUVs composed of dioleoylphosphatidylcholine, dioleoylphosphatidylethanolamin...
AbstractIn this study, we performed all-atom long-timescale molecular dynamics simulations of phosph...
his thesis aimed to support the current model of membrane fusion by (1) providing an avenue towards ...
AbstractPEG-mediated fusion of SUVs composed of dioleoylphosphatidylcholine, dioleoylphosphatidyleth...
The fusion of a membrane-bounded vesicle with a target membrane is a key step in intracellular traff...
Membrane fusion is a key step in intracellular trafficking and viral infection. The underlying molec...
AbstractMembrane fusion is essential for intracellular trafficking and virus infection, but the mole...
AbstractMembrane fusion is a key event in vesicular trafficking in every cell, and many fusion-relat...
Membrane fusion, essential to eukaryotic life, is broadly envisioned as a three-step process proceed...
In this review, we describe the recent contribution of computer simulation approaches to unravel the...
We report on the mechanism of membrane fusion mediated by polyethylene glycol (PEG) and Ca2+ by mean...
The researches performed in this dissertation is aimed to solve the role of calcium in the membrane ...
The effect of viscosity on the encounter rate of two interacting membranes was investigated by combi...
This project is focused on understanding the role of calcium in membrane fusion at the atomic level....
AbstractAlthough membrane fusion plays key roles in intracellular trafficking, neurotransmitter rele...
PEG-mediated fusion of SUVs composed of dioleoylphosphatidylcholine, dioleoylphosphatidylethanolamin...
AbstractIn this study, we performed all-atom long-timescale molecular dynamics simulations of phosph...
his thesis aimed to support the current model of membrane fusion by (1) providing an avenue towards ...
AbstractPEG-mediated fusion of SUVs composed of dioleoylphosphatidylcholine, dioleoylphosphatidyleth...
The fusion of a membrane-bounded vesicle with a target membrane is a key step in intracellular traff...
Membrane fusion is a key step in intracellular trafficking and viral infection. The underlying molec...
AbstractMembrane fusion is essential for intracellular trafficking and virus infection, but the mole...
AbstractMembrane fusion is a key event in vesicular trafficking in every cell, and many fusion-relat...
Membrane fusion, essential to eukaryotic life, is broadly envisioned as a three-step process proceed...
In this review, we describe the recent contribution of computer simulation approaches to unravel the...