Add to ORKGA combination of cytogenetic and molecular studies has implicated the p21 region of human chromosome 3 as the probable site of a gene the loss of which contributes to the development of small cell lung cancer. We report here the isolation of a gene from this region which is expressed in normal lung tissue and in cell lines derived from a number of different types of tumor, but the expression of which in small cell lung cancer cell lines is undetectable by RNA blot analysis. Although the more sensitive polymerase chain reaction did detect transcripts, a novel quantitative polymerase chain reaction assay showed that their concentration in small cell lung cancer cell lines is less than 3% of that in normal lung.</p
A newly identified gene, p51, is a functional and struc-tural homologue of the p53 gene and thus a c...
Background : Loss of the short arm of chromosome 16 is a frequent event in various cancers, which su...
AbstractA newly identified gene, p51, is a functional and structural homologue of the p53 gene and t...
A combination of cytogenetic and molecular studies has implicated the p21 region of human chromosome...
High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) a...
We have developed a general PCR-based method to quantify the amount of a specific mRNA present in a ...
Previous karyotypic analysis of human small cell lung cancer cell lines has demonstrated a consisten...
In childhood malignancies such as retinoblastoma and Wilms tumour, of which both familial and sporad...
The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently c...
We used overlapping and nested homozygous deletions, contig building, genomic sequencing, and physic...
We used 10 restriction fragment length polymorphism (RFLP) probes spanning the length of the short a...
In the search for a tumour suppressor gene in the 3P21.3 region we isolated two genes, RBM5 and RBM6...
The early and frequent occurrence of deletions at 3p21.3 in lung cancer has led to the consideration...
A newly identified gene, p51, is a functional and struc-tural homologue of the p53 gene and thus a c...
Background : Loss of the short arm of chromosome 16 is a frequent event in various cancers, which su...
AbstractA newly identified gene, p51, is a functional and structural homologue of the p53 gene and t...
A combination of cytogenetic and molecular studies has implicated the p21 region of human chromosome...
High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) a...
We have developed a general PCR-based method to quantify the amount of a specific mRNA present in a ...
Previous karyotypic analysis of human small cell lung cancer cell lines has demonstrated a consisten...
In childhood malignancies such as retinoblastoma and Wilms tumour, of which both familial and sporad...
The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently c...
We used overlapping and nested homozygous deletions, contig building, genomic sequencing, and physic...
We used 10 restriction fragment length polymorphism (RFLP) probes spanning the length of the short a...
In the search for a tumour suppressor gene in the 3P21.3 region we isolated two genes, RBM5 and RBM6...
The early and frequent occurrence of deletions at 3p21.3 in lung cancer has led to the consideration...
A newly identified gene, p51, is a functional and struc-tural homologue of the p53 gene and thus a c...
Background : Loss of the short arm of chromosome 16 is a frequent event in various cancers, which su...
AbstractA newly identified gene, p51, is a functional and structural homologue of the p53 gene and t...