Interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) are considered as important mediators for the modulation of liver synthesis of acute phase proteins. However, studies of the direct effect of individual or a combination of these cytokines on the synthesis of acute phase proteins in human hepatocytes are still very limited. In this study, we have examined the synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes exposed to recombinant(r)IL-1-alpha (100 U/ml), rIL-6 (2000 U/ml), rTNF-alpha (30 U/ml) and to various combinations of these cytokines in the presence of 1-mu-M dexamethasone. Monoclonal antibodies to rTNF-alpha and monospecific anti-rIL-6 sheep antiserum were also used to inv...
Tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) play a main role in indu...
Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver r...
Macrophage inhibitory factor (MIF) is a pituitary peptide released during the physiological stress r...
Interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) are considered as important mediators for t...
AbstractThe three monokines interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and interleukin-...
C-reactive protein (CRP) and serum amyloid A protein (SAA) are acute- phase proteins produced by the...
The involvement of tumor necrosis factor alpha (TNF alpha) in the regulation of acute-phase protein ...
AbstractRecombinant human IL-6 (rhIL-6) is a potent inducer of the synthesis of acute phase proteins...
It has been suggested that, as part of the inflammatory response to the presence of a tumor, various...
: Three secretory products of the macrophage, interleukin 1 (IL-1), tumor necrosis factor/cachectin ...
IL-6 regulates the synthesis of a broad spectrum of acute phase proteins in the liver. Also, it is i...
AbstractInterleukin 4 (IL4) has been shown to exhibit anti-inflammatory effects by inhibiting the se...
Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is consid...
Tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) play a main role in indu...
Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver r...
Macrophage inhibitory factor (MIF) is a pituitary peptide released during the physiological stress r...
Interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF) are considered as important mediators for t...
AbstractThe three monokines interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and interleukin-...
C-reactive protein (CRP) and serum amyloid A protein (SAA) are acute- phase proteins produced by the...
The involvement of tumor necrosis factor alpha (TNF alpha) in the regulation of acute-phase protein ...
AbstractRecombinant human IL-6 (rhIL-6) is a potent inducer of the synthesis of acute phase proteins...
It has been suggested that, as part of the inflammatory response to the presence of a tumor, various...
: Three secretory products of the macrophage, interleukin 1 (IL-1), tumor necrosis factor/cachectin ...
IL-6 regulates the synthesis of a broad spectrum of acute phase proteins in the liver. Also, it is i...
AbstractInterleukin 4 (IL4) has been shown to exhibit anti-inflammatory effects by inhibiting the se...
Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is consid...
Tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) play a main role in indu...
Background: Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver r...
Macrophage inhibitory factor (MIF) is a pituitary peptide released during the physiological stress r...