Localization patterns of germinal center cell subsets differing in density and in sedimentation velocity

In a previous study (Opstelten et al., 1981a) germinal center cells of the rabbit appendix, labeled in vitro with 3H-leucine and injected i.v. in homologous recipients, were shown to contain a rather exceptional B cell population which localizes in splenic germinal centers. In contrast, B lymphocytes from rabbit spleen, appendix dome and thoracic duct lymph exhibited the more common B cell localization pattern, i.e. — in the spleen — only in the corona of secondary follicles (Parrott, 1967; Parrott and de Sousa; 1971; Ford, 1975; Nieuwenhuis and Ford, 1976)