Add to ORKGObesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The development of these metabolic disorders is frequently studied, but mainly in liver, skeletal muscle, and adipose tissue. To gain more insight in the role of the small intestine in development of obesity and insulin resistance, dietary fat-induced differential gene expression was determined along the longitudinal axis of small intestines of C57BL/6J mice. METHODS: Male C57BL/6J mice were fed a low-fat or a high-fat diet that mimicked the fatty acid composition of a Western-style human diet. After 2, 4 and 8 weeks of diet intervention small intestines were isolated and divided in three equal parts. Differential gene expression was determined in m...
Ng Ki67-specific antibodies. Besides the villus length (A) and total number of villus cells (B), als...
Background: A high caloric diet, in conjunction with low levels of physical activity, promotes obesi...
As the prevalence of childhood obesity increases in the United States, the prevalence of obesity-rel...
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The dev...
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain...
An increasing amount of evidence suggests that the small intestine may play an important role in the...
are clustered in a heat map diagram for the proximal, middle and distal part of the small intestine....
Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. ...
Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. ...
Of nuclear (hormone) receptors and their target genes was determined by microarray analysis, after 2...
N at least one week of diet intervention are plotted (grey bars). Among those are genes that were co...
Ly expressed genes with fold changes < -1.5 and > +1.5 in at least one week of diet intervention. Re...
Ined after 2 weeks of low-fat diet intervention. qPCR data of the nuclear receptors are visualized a...
Ance test was performed after 7 weeks of diet intervention. After an oral gavage of 100 mg glucose, ...
Ance test was performed after 7 weeks of diet intervention. After an oral gavage of 100 mg glucose, ...
Ng Ki67-specific antibodies. Besides the villus length (A) and total number of villus cells (B), als...
Background: A high caloric diet, in conjunction with low levels of physical activity, promotes obesi...
As the prevalence of childhood obesity increases in the United States, the prevalence of obesity-rel...
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. The dev...
Obesity and insulin resistance are two major risk factors underlying the metabolic syndrome. To gain...
An increasing amount of evidence suggests that the small intestine may play an important role in the...
are clustered in a heat map diagram for the proximal, middle and distal part of the small intestine....
Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. ...
Excessive intake of dietary fat is known to be a contributing factor in the development of obesity. ...
Of nuclear (hormone) receptors and their target genes was determined by microarray analysis, after 2...
N at least one week of diet intervention are plotted (grey bars). Among those are genes that were co...
Ly expressed genes with fold changes < -1.5 and > +1.5 in at least one week of diet intervention. Re...
Ined after 2 weeks of low-fat diet intervention. qPCR data of the nuclear receptors are visualized a...
Ance test was performed after 7 weeks of diet intervention. After an oral gavage of 100 mg glucose, ...
Ance test was performed after 7 weeks of diet intervention. After an oral gavage of 100 mg glucose, ...
Ng Ki67-specific antibodies. Besides the villus length (A) and total number of villus cells (B), als...
Background: A high caloric diet, in conjunction with low levels of physical activity, promotes obesi...
As the prevalence of childhood obesity increases in the United States, the prevalence of obesity-rel...