PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per fat cell. We investigated whether ligand availability for PPAR¿ is rate limiting in fat mass generation and substrate metabolism. Twenty healthy men (20¿29 years) were randomly assigned to receive the PPAR¿ ligand rosiglitazone (RSG) (8 mg/d) (n 10) or a placebo (n 10) during a stay of 7 d in a respiration chamber. Food intake was ad libitum, resulting in positive energy balances of 32·2 MJ (placebo) and 44·7 MJ (RSG). Fat cell size and expression of PPAR¿, adipocyte fatty acid-binding protein (aP2), adipsin, adiponectin and fasting-induced adipose factor (FIAF) were determined in subcutaneous abdominal fat biopsies. The total amount of fat ...
Evidence points to a role of the mammalian target of rapamycin (mTOR) signaling pathway as a regulat...
International audienceThis work aimed at characterizing the role of peroxisome proliferator-activate...
Aims: To accommodate surplus energy, adipose tissue expands by increasing both adipose cell size (hy...
PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per...
PPARgamma is obligatory for fat mass generation and is thought to determine the amount of TAG stored...
BACKGROUND AND AIM: Fat mass generation requires an energy surplus and the activity of the peroxisom...
Thiazolidinediones (TZD) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that may ...
Objective We investigated whether PPAR? modulates adipose tissue BCAA metabolism, and whether this ...
Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while w...
Treatment with rosiglitazone, a potent peroxisome proliferator–activated receptor (PPAR) γ agonist, ...
Peroxisome proliferator-activated receptors (PPARs) participate in the molecular mechanism of pathol...
AIMS/HYPOTHESIS: The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated re...
Aims/hypothesis: The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated re...
Due to a sedentary lifestyle and an energy-dense diet the prevalence obesity rapidly increases in in...
(A) Addition of rosiglitazone (1 μm) to the differentiation stimulus (DMI) rescues the loss of adipo...
Evidence points to a role of the mammalian target of rapamycin (mTOR) signaling pathway as a regulat...
International audienceThis work aimed at characterizing the role of peroxisome proliferator-activate...
Aims: To accommodate surplus energy, adipose tissue expands by increasing both adipose cell size (hy...
PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per...
PPARgamma is obligatory for fat mass generation and is thought to determine the amount of TAG stored...
BACKGROUND AND AIM: Fat mass generation requires an energy surplus and the activity of the peroxisom...
Thiazolidinediones (TZD) are peroxisome proliferator-activated receptor γ (PPARγ) agonists that may ...
Objective We investigated whether PPAR? modulates adipose tissue BCAA metabolism, and whether this ...
Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat while w...
Treatment with rosiglitazone, a potent peroxisome proliferator–activated receptor (PPAR) γ agonist, ...
Peroxisome proliferator-activated receptors (PPARs) participate in the molecular mechanism of pathol...
AIMS/HYPOTHESIS: The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated re...
Aims/hypothesis: The thiazolidinedione (TZD) rosiglitazone is a peroxisome proliferator-activated re...
Due to a sedentary lifestyle and an energy-dense diet the prevalence obesity rapidly increases in in...
(A) Addition of rosiglitazone (1 μm) to the differentiation stimulus (DMI) rescues the loss of adipo...
Evidence points to a role of the mammalian target of rapamycin (mTOR) signaling pathway as a regulat...
International audienceThis work aimed at characterizing the role of peroxisome proliferator-activate...
Aims: To accommodate surplus energy, adipose tissue expands by increasing both adipose cell size (hy...