Myopia as a Risk Factor for Open-Angle Glaucoma:A Systematic Review and Meta-Analysis

Objective: To determine the association between myopia and open-angle glaucoma.Design: Systematic review and meta-analysis of observational studies.Participants: Thirteen studies involving 48 161 individuals.Methods: Articles published between 1994 and 2010 were identified in PubMed, Embase, and reference lists. Study-specific odds ratios (ORs) were pooled using a random effects model.Main Outcome Measures: Odds ratios with 95% confidence intervals (CIs) of myopia as a risk factor for open-angle glaucoma.Results: Data from 11 population-based cross-sectional studies were included in the main analyses. The pooled OR of the association between myopia and glaucoma based on 11 risk estimates was 1.92 (95% CI, 1.54-2.38). On the basis of 7 risk estimates, the pooled ORs of the associations between low myopia (myopia up to -3 D) and glaucoma and between high myopia (Conclusions: Individuals with myopia have an increased risk of developing open-angle glaucoma. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2011;118:1989-1994 (C) 2011 by the American Academy of Ophthalmology.