To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase inhibitor, both random mutagenesis approaches and rational engineering of Streptomyces clavuligerus strains have been extensively applied. Here, for the first time, we compared genome-wide gene expression of an industrial S. clavuligerus strain, obtained through iterative mutagenesis, with that of the wild-type strain. Intriguingly, we found that the majority of the changes contributed not to a complex rewiring of primary metabolism but consisted of a simple upregulation of various antibiotic biosynthesis gene clusters. A few additional transcriptional changes in primary metabolism at key points seem to divert metabolic fluxes to the biosynthet...
Bacterial specialized metabolites are of immense importance because of their medicinal, industrial, ...
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is use...
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is use...
To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase in...
To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase in...
To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase in...
To increase production of the important pharmaceutical compound clavulanic acid, a β-lactamase inhib...
Summary To increase production of the important pharmaceutical compound clavulanic acid, a +¦-lactam...
Contains fulltext : 97938.pdf (publisher's version ) (Open Access)To increase prod...
Natural products derived from the secondary metabolism of microbes constitute a cornerstone of moder...
Natural products derived from the secondary metabolism of microbes constitute a cornerstone of moder...
Item does not contain fulltextNatural products derived from the secondary metabolism of microbes con...
AbstractThe usefulness of genetic/metabolic engineering for further improvement of industrial strain...
The usefulness of genetic/metabolic engineering for further improvement of industrial strains is sub...
AbstractThe usefulness of genetic/metabolic engineering for further improvement of industrial strain...
Bacterial specialized metabolites are of immense importance because of their medicinal, industrial, ...
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is use...
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is use...
To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase in...
To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase in...
To increase production of the important pharmaceutical compound clavulanic acid, a beta-lactamase in...
To increase production of the important pharmaceutical compound clavulanic acid, a β-lactamase inhib...
Summary To increase production of the important pharmaceutical compound clavulanic acid, a +¦-lactam...
Contains fulltext : 97938.pdf (publisher's version ) (Open Access)To increase prod...
Natural products derived from the secondary metabolism of microbes constitute a cornerstone of moder...
Natural products derived from the secondary metabolism of microbes constitute a cornerstone of moder...
Item does not contain fulltextNatural products derived from the secondary metabolism of microbes con...
AbstractThe usefulness of genetic/metabolic engineering for further improvement of industrial strain...
The usefulness of genetic/metabolic engineering for further improvement of industrial strains is sub...
AbstractThe usefulness of genetic/metabolic engineering for further improvement of industrial strain...
Bacterial specialized metabolites are of immense importance because of their medicinal, industrial, ...
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is use...
Streptomyces clavuligerus produces the potent beta-lactamase inhibitor clavulanic acid, which is use...