Prognostic Relevance of Immunohistochemical Subclassification of Diffuse Large B-Cell Lymphoma in Two Prospective Phase III Clinical Trials
- Rayman, Nazik
- Lam, King H.
- van der Holt, Bronno
- Koss, Clara
- Veldhuizen, Dennis
- Budel, Leo M.
- Mulder, Andries H.
- Verdonck, Leo F.
- Delwel, Ruud
- de Jong, Daphne
- van Imhoff, Gustaaf W.
- Sonneveld, Pieter
Publication date
February 2011
DOIAbstract
Purpose: Until now molecular biologic techniques have not been easily used in daily clinical practice to stratify patients for therapeutic purposes. Therefore, we have investigated the prognostic relevance of the immunohistochemical (IHC) germinal center B-cell (GCB) versus non-GCB diffuse large B-cell lymphoma (DLBCL) subtypes. Patient; and Methods: We have analyzed tumor samples from patients treated in 2 prospective multicenter phase III trials, ie HOVON 25 (patients >= 65 years, n = 153) and HOVON 26 (patients</p
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