There is still limited knowledge about the interrelations among the age of initiation of different substances and the diverse aspects of adolescent functioning. The present cross-national study aimed at exploring the presence of a time-order pattern of age of initiation of different substances and the relationships with personal and relational resources and vulnerabilities, drawn from the problem behaviour theory by Jessor et al. (1991). The sample consisted of 970 adolescents from Italy and The Netherlands, of whom 198 were fully initiated in alcohol, first tobacco use, regular tobacco smoking and marijuana. In both countries, cumulative scale analyses showed the presence of a pattern of age of initiation in the different types of substanc...