Phosphoramidite accelerated copper(I)-catalyzed [3+2] cycloadditions of azides and alkynes
- Campbell-Verduyn, Lachlan S.
- Mirfeizi, Leila
- Dierckx, Rudi A.
- Elsinga, Philip H.
- Feringa, Ben L.
Publication date
January 2009
DOIAbstract
Monodentate phosphoramidite ligands are used to accelerate the copper(I)-catalyzed 1,3-dipolar cycloaddition of azides and alkynes (CuAAC) rapidly yielding a wide variety of functionalized 1,4-disubstituted-1,2,3-triazoles; Cu(I) and Cu(II) salts both function as the copper source in aqueous solution to provide excellent yields.</p
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