Differential NF-¿B pathways induction by Lactobacillus plantarum in the duodenum of healthy humans correlating with immune tolerance
- Baarlen, P., van
- Troost, F.J.
- Hemert, S., van
- Meer, C., van der
- Vos, W.M., de
- Groot, P.J., de
- Hooiveld, G.J.E.J.
- Brummer, R.J.
- Kleerebezem, M.
DOIAbstract
How do we acquire immune tolerance against food microorganisms and commensal bacteria that constitute the intestinal microbiota? We investigated this by stimulating the immune system of adults with commensal Lactobacillus plantarum bacteria. We studied the in vivo human responses to L. plantarum in a randomized double-blind placebo-controlled cross-over study. Healthy adults ingested preparations of living and heat-killed L. plantarum bacteria. Biopsies were taken from the intestinal duodenal mucosa and altered expression profiles were analyzed using whole-genome microarrays and by biological pathway reconstructions. Expression profiles of human mucosa displayed striking differences in modulation of NF-¿B-dependent pathways, notably after c...
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