A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
- van Heel, David A.
- Franke, Lude
- Hunt, Karen A.
- Gwilliam, Rhian
- Zhernakova, Alexandra
- Inouye, Mike
- Wapenaar, Martin C
- Barnardo, Martin C. N. M.
- Bethel, Graeme
- Holmes, Geoffrey K. T.
- Feighery, Con
- Jewell, Derek
- Kelleher, Dermot
- Kumar, Parveen
- Travis, Simon
- Walters, Julian R. F.
- Sanders, David S.
- Howdle, Peter
- Swift, Jill
- Playford, Raymond J.
- McLaren, William M.
- Mearin, M. Luisa
- Mulder, Chris J.
- McManus, Ross
- McGinnis, Ralph
- Cardon, Lon R.
- Deloukas, Panos
- Wijmenga, Cisca
Publication date
July 2007
DOIAbstract
We tested 310,605 SNPs for association in 778 individuals with celiac disease and 1,422 controls. Outside the HLA region, the most significant finding ( rs13119723; P = 2.0 x 10(-7)) was in the KIAA1109- TENR- IL2- IL21 linkage disequilibrium block. We independently confirmed association in two further collections ( strongest association at rs6822844, 24 kb 5' of IL21; meta-analysis P = 1.3 x 10(- 14), odds ratio 0.63), suggesting that genetic variation in this region predisposes to celiac disease.</p
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