Add to ORKGThe BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DNA repair and transcriptional regulation. Here we identify a protein, EMSY, which binds BRCA2 within a region (exon 3) deleted in cancer. EMSY is capable of silencing the activation potential of BRCA2 exon 3, associates with chromatin regulators HP1beta and BS69, and localizes to sites of repair following DNA damage. EMSY maps to chromosome 11q13.5, a region known to be involved in breast and ovarian cancer. We show that the EMSY gene is amplified almost exclusively in sporadic breast cancer (13%) and higher-grade ovarian cancer (17%). In addition, EMSY amplification is associated with worse survival, particularly in node-negative breast cance...
The EMSY gene encodes a protein that interacts with Brca2 and is amplifi ed in some sporadic cases o...
BRCA1 interacts with several proteins implicated in homologous and non homologous recombination and ...
Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovaria...
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DN...
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DN...
AbstractThe BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicat...
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DN...
EMSY is a novel gene encoding a protein that binds to the tumor suppressor BRCA2. EMSY maps to 11q1...
AbstractIn this issue, Hughes-Davies et al. describe a novel gene product, EMSY, which suppresses th...
Abstract: Mutations in the breast cancer susceptibility gene 2 (BRCA2) are commonly found in familia...
AbstractCheckpoint proteins are activated in response to genotoxic insults or replication stress to ...
PURPOSE: Male breast cancer (MBC) is a rare disease that shares some similarities with female breas...
Abstract Background BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susce...
Background: Male breast cancer (MBC) is a rare disease compared to female breast cancer (FBC). MBC s...
The inheritance of monoallelic germline mutations affecting BRCA1 or BRCA2 predisposes with a high p...
The EMSY gene encodes a protein that interacts with Brca2 and is amplifi ed in some sporadic cases o...
BRCA1 interacts with several proteins implicated in homologous and non homologous recombination and ...
Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovaria...
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DN...
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DN...
AbstractThe BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicat...
The BRCA2 gene is mutated in familial breast and ovarian cancer, and its product is implicated in DN...
EMSY is a novel gene encoding a protein that binds to the tumor suppressor BRCA2. EMSY maps to 11q1...
AbstractIn this issue, Hughes-Davies et al. describe a novel gene product, EMSY, which suppresses th...
Abstract: Mutations in the breast cancer susceptibility gene 2 (BRCA2) are commonly found in familia...
AbstractCheckpoint proteins are activated in response to genotoxic insults or replication stress to ...
PURPOSE: Male breast cancer (MBC) is a rare disease that shares some similarities with female breas...
Abstract Background BRCA1 and BRCA2 mutations explain approximately one-fifth of the inherited susce...
Background: Male breast cancer (MBC) is a rare disease compared to female breast cancer (FBC). MBC s...
The inheritance of monoallelic germline mutations affecting BRCA1 or BRCA2 predisposes with a high p...
The EMSY gene encodes a protein that interacts with Brca2 and is amplifi ed in some sporadic cases o...
BRCA1 interacts with several proteins implicated in homologous and non homologous recombination and ...
Inherited mutations in the BRCA2 gene predispose individuals to the development of breast and ovaria...