Add to ORKGCowden disease (CD) is characterised by multiple hamartomas in a variety of tissues. The pathological hallmark is the presence of a number of trichilemmomas. Several neurological symptoms are also part of CD with megalencephaly and Lhermitte-Duclos disease (LDD) as the most important features. Early recognition of CD patients is important because of the increased risk of developing malignancies. Breast cancer is the most frequent malignancy, but also urogenital, digestive tract, and thyroid cancers are found,vith higher frequencies. CD was localised to chromosome 10q23 and the PTEN gene (also known as MMAC1 or TEP1) was shown to be involved. Germline mutations were identified in both familial and sporadic CD patients. We identified eight PT...
Kersseboom R, Dubbink HJ, Corver WE, van Tilburg AJP, Poley JW, van Leerdam ME, Atmodimedjo PN, van ...
Patients with heritable cancer syndromes characterized by germline PTEN mutations (termed PTEN hamar...
Cowden syndrome (OMIM No. 158350) and Bannayan-Riley-Ruvalcaba syndrome (BRRS) (OMIM No. 153480) are...
Cowden disease (CD) is characterised by multiple hamartomas in a variety of tissues. The pathologica...
Cowden disease, also known as multiple hamartoma syndrome, is a rare disease inherited in an autosom...
Cowden syndrome (CS) is an infrequent genodermatosis caused by mutations in the phosphatase and tens...
Cowden syndrome (CS) is a phosphatase and tensin homolog gene (PTEN) -associated condition character...
Cowden disease, also known as multiple hamartoma syndrome, is an autosomal dominant cancer syndrome ...
Cowden disease (CD) is an autosomal dominant multiple hamartoma syndrome with an elevated risk of th...
Cowden syndrome (CS), an autosomal dominant disorder, is associated with germline mutations of the P...
Cowden syndrome (CS) or multiple hamartoma syndrome (MIM 158350) is an autosomal dominant disorder w...
Cowden syndrome (CS) or multiple hamartoma syndrome (MIM 158350) is an autosomal dominant disorder w...
Cowden syndrome (CS) is a rare disease that was first described in 1963 and later included in the la...
Abstract Background Cowden syndrome (CS) is a cancer predisposition syndrome associated with increas...
Cowden syndrome (CS) is a difficult-to-recognize multiple hamartoma syndrome with high risks of brea...
Kersseboom R, Dubbink HJ, Corver WE, van Tilburg AJP, Poley JW, van Leerdam ME, Atmodimedjo PN, van ...
Patients with heritable cancer syndromes characterized by germline PTEN mutations (termed PTEN hamar...
Cowden syndrome (OMIM No. 158350) and Bannayan-Riley-Ruvalcaba syndrome (BRRS) (OMIM No. 153480) are...
Cowden disease (CD) is characterised by multiple hamartomas in a variety of tissues. The pathologica...
Cowden disease, also known as multiple hamartoma syndrome, is a rare disease inherited in an autosom...
Cowden syndrome (CS) is an infrequent genodermatosis caused by mutations in the phosphatase and tens...
Cowden syndrome (CS) is a phosphatase and tensin homolog gene (PTEN) -associated condition character...
Cowden disease, also known as multiple hamartoma syndrome, is an autosomal dominant cancer syndrome ...
Cowden disease (CD) is an autosomal dominant multiple hamartoma syndrome with an elevated risk of th...
Cowden syndrome (CS), an autosomal dominant disorder, is associated with germline mutations of the P...
Cowden syndrome (CS) or multiple hamartoma syndrome (MIM 158350) is an autosomal dominant disorder w...
Cowden syndrome (CS) or multiple hamartoma syndrome (MIM 158350) is an autosomal dominant disorder w...
Cowden syndrome (CS) is a rare disease that was first described in 1963 and later included in the la...
Abstract Background Cowden syndrome (CS) is a cancer predisposition syndrome associated with increas...
Cowden syndrome (CS) is a difficult-to-recognize multiple hamartoma syndrome with high risks of brea...
Kersseboom R, Dubbink HJ, Corver WE, van Tilburg AJP, Poley JW, van Leerdam ME, Atmodimedjo PN, van ...
Patients with heritable cancer syndromes characterized by germline PTEN mutations (termed PTEN hamar...
Cowden syndrome (OMIM No. 158350) and Bannayan-Riley-Ruvalcaba syndrome (BRRS) (OMIM No. 153480) are...