Enantiomeric excess determination without chiral auxiliary compounds. A new phosphorus-31 NMR method for amino acid esters and primary amines
- Feringa, Ben L.
- Strijtveen, Bert
- Kellogg, Richard M.
Publication date
December 1986
DOIAbstract
Amino acid esters and primary amines yield diastereoisomeric methylphosphonic diamides 5 upon reaction with MePSCl2. The enantiomeric excess of amino acid esters and amines is easily determined by measurement of the ratio of diastereoisomers of 5 by 31P NMR spectroscopy
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