Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry
- Peters, R.J.B.
- Stolker, A.A.M.
- Mol, J.G.J.
- Lommen, A.
- Lyris, E.
- Angelis, Y.S.
- Vonaparti, A.
- Stamou, M.
- Georgakopoulos, C.G.
- Nielen, M.W.F.
DOIAbstract
A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward. We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOF-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact o...
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