Detailed evaluation of coronary function early in diabetes mellitus (DM)-associated coronary artery disease (CAD) development is difficult in patients. Therefore, we investigated coronary conduit and small artery function in a preatherosclerotic DM porcine model with type 2 characteristics. Streptozotocin-induced DM pigs on a saturated fat/cholesterol (SFC) diet (SFC + DM) were compared with control pigs on SFC and standard (control) diets. SFC + DM pigs showed DM-associated metabolic alterations and early atherosclerosis development in the aorta. Endothelium-dependent vasodilation to bradykinin (BK), with or without blockade of nitric oxide (NO) synthase, endothelium-independent vasodilation to an exogenous NO-donor (S-nitroso-N-acetylpeni...
Background: The leptin receptor-deficient db/db mouse is a well-established type II diabetes animal ...
AbstractStudies in human and non-human primates have confirmed the compensatory enlargement or posit...
Background: The causal factors underpinning the onset and progression of diabetic heart disease (DHD...
Coronary microvascular dysfunction (CMD) has been proposed as an important component of diabetes mel...
microvascular dysfunction in a porcine model of early atherosclerosis and diabete
Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compar...
SummaryPatients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events...
Background—Animal models used to gain insight into the vascular response to drug-eluting stents are ...
Background: We studied the effect of bioresorbable vascular scaffold (BVS) implantation on distal co...
Background Atherosclerosis causes over 40% of all deaths in the USA and Western Europe. Although sev...
In the present study, we tested the hypothesis that multiple risk factors, including diabetes mellit...
Abstract Background Diabetes remains a significant risk factor for restenosis/thrombosis following s...
Studies in human and non-human primates have confirmed the compensatory enlargement or positive remo...
Studies in human and non-human primates have confirmed the compensatory enlargement or positive remo...
<div><p>Background</p><p>Insulin-resistant subjects develop more severe and diffuse coronary artery ...
Background: The leptin receptor-deficient db/db mouse is a well-established type II diabetes animal ...
AbstractStudies in human and non-human primates have confirmed the compensatory enlargement or posit...
Background: The causal factors underpinning the onset and progression of diabetic heart disease (DHD...
Coronary microvascular dysfunction (CMD) has been proposed as an important component of diabetes mel...
microvascular dysfunction in a porcine model of early atherosclerosis and diabete
Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compar...
SummaryPatients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events...
Background—Animal models used to gain insight into the vascular response to drug-eluting stents are ...
Background: We studied the effect of bioresorbable vascular scaffold (BVS) implantation on distal co...
Background Atherosclerosis causes over 40% of all deaths in the USA and Western Europe. Although sev...
In the present study, we tested the hypothesis that multiple risk factors, including diabetes mellit...
Abstract Background Diabetes remains a significant risk factor for restenosis/thrombosis following s...
Studies in human and non-human primates have confirmed the compensatory enlargement or positive remo...
Studies in human and non-human primates have confirmed the compensatory enlargement or positive remo...
<div><p>Background</p><p>Insulin-resistant subjects develop more severe and diffuse coronary artery ...
Background: The leptin receptor-deficient db/db mouse is a well-established type II diabetes animal ...
AbstractStudies in human and non-human primates have confirmed the compensatory enlargement or posit...
Background: The causal factors underpinning the onset and progression of diabetic heart disease (DHD...