Add to ORKGBackground Studies in mice have shown that PPARa is an important regulator of lipid metabolism in liver and key transcription factor involved in the adaptive response to fasting. However, much less is known about the role of PPARa in human liver. Methods Here we set out to study the function of PPARa in human liver via analysis of whole genome gene regulation in human liver slices treated with the PPARa agonist Wy14643. Results Quantitative PCR indicated that PPARa is well expressed in human liver and human liver slices and that the classical PPARa targets PLIN2, VLDLR, ANGPTL4, CPT1A and PDK4 are robustly induced by PPARa activation. Transcriptomics analysis indicated that 617 genes were upregulated and 665 genes were downregulated by PPAR...
The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known ab...
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the ...
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the ...
Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in l...
Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in l...
BACKGROUND: Studies in mice have shown that PPARalpha is an important regulator of lipid metabolism ...
Background - Studies in mice have shown that PPARa is an important regulator of hepatic lipid metabo...
Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to bett...
Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to bett...
Little is known about the role of the transcription factor peroxisome proliferator-activated recepto...
For many tissues fatty acids represent the major source of fuel. In the past few decades it has beco...
Background The peroxisome proliferator-activated receptor alpha (PPARa) is a ligand-activated transc...
PPARa is a ligand-activated transcription factor involved in the regulation of nutrient metabolism a...
The peroxisome proliferator activated receptor alpha (PPARα) is a ligand activated tran- scription f...
The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription...
The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known ab...
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the ...
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the ...
Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in l...
Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in l...
BACKGROUND: Studies in mice have shown that PPARalpha is an important regulator of lipid metabolism ...
Background - Studies in mice have shown that PPARa is an important regulator of hepatic lipid metabo...
Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to bett...
Little is known about the role of the transcription factor PPARß/d in liver. Here we set out to bett...
Little is known about the role of the transcription factor peroxisome proliferator-activated recepto...
For many tissues fatty acids represent the major source of fuel. In the past few decades it has beco...
Background The peroxisome proliferator-activated receptor alpha (PPARa) is a ligand-activated transc...
PPARa is a ligand-activated transcription factor involved in the regulation of nutrient metabolism a...
The peroxisome proliferator activated receptor alpha (PPARα) is a ligand activated tran- scription f...
The peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription...
The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known ab...
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the ...
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the ...