Current antibiotic therapies for bacterial pathogens target common components essential for viability of all bacteria. This strategy has been very effective in combating bacterial infections but fails to discriminate against non-pathogens and places tremendous pressure on organisms to evolve antibiotic resistance mechanisms. A promising alternative to targeting bacterial viability is to inhibit virulence mechanisms that are unique to pathogenic bacteria and modulate interaction with the host. Gram-negative bacteria utilize a type three secretion system (T3SS) to inject effector molecules from the bacterial cytoplasm directly into the host, where the effectors subvert and modify host cell function for colonization and immune evasion. Using...
Numerous human, animal, and plant pathogenic strains of Gram-negative bacteria have been shown to pr...
Several pathogenic Gram-negative bacteria, including Salmonella, Shigella, Yersinia, Pseudomonas aer...
Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients...
The recent and dramatic rise of antibiotic resistance among bacterial pathogens underlies the fear t...
Drug-resistant pathogens have presented increasing challenges to the discovery and development of ne...
Infections caused by Gram-negative pathogens pose a major health burden. Both respiratory and gastro...
Antibiotic resistance in pathogens requires new targets for developing novel antibacterials. The bac...
SummaryBacterial virulence mechanisms are attractive targets for antibiotic development because they...
The aims of my dissertation research were to characterize the activity of inhibitors targeting the b...
The prevalence of bacterial pathogens being resistant to antibiotic treatment is increasing worldwid...
The injectisome type three secretion system (T3SS) is a major virulence factor in Pseudomonas aerugi...
Commonly used antibiotics are becoming less effective; therefore, the development of new antimicrobi...
Commonly used antibiotics are becoming less effective because they target bacterial cell walls or pr...
The aims of my dissertation research were to determine how a bacterial virulence factor, the type II...
Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections ...
Numerous human, animal, and plant pathogenic strains of Gram-negative bacteria have been shown to pr...
Several pathogenic Gram-negative bacteria, including Salmonella, Shigella, Yersinia, Pseudomonas aer...
Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients...
The recent and dramatic rise of antibiotic resistance among bacterial pathogens underlies the fear t...
Drug-resistant pathogens have presented increasing challenges to the discovery and development of ne...
Infections caused by Gram-negative pathogens pose a major health burden. Both respiratory and gastro...
Antibiotic resistance in pathogens requires new targets for developing novel antibacterials. The bac...
SummaryBacterial virulence mechanisms are attractive targets for antibiotic development because they...
The aims of my dissertation research were to characterize the activity of inhibitors targeting the b...
The prevalence of bacterial pathogens being resistant to antibiotic treatment is increasing worldwid...
The injectisome type three secretion system (T3SS) is a major virulence factor in Pseudomonas aerugi...
Commonly used antibiotics are becoming less effective; therefore, the development of new antimicrobi...
Commonly used antibiotics are becoming less effective because they target bacterial cell walls or pr...
The aims of my dissertation research were to determine how a bacterial virulence factor, the type II...
Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections ...
Numerous human, animal, and plant pathogenic strains of Gram-negative bacteria have been shown to pr...
Several pathogenic Gram-negative bacteria, including Salmonella, Shigella, Yersinia, Pseudomonas aer...
Pseudomonas aeruginosa is a cause of high mortality in burn, immunocompromised, and surgery patients...