Design and Synthesis of Substituted N,3,3-Triphenylpropanamide and 1-Benzhydryl-N-phenylazetidine-3-carboxamide Analogs and their Biological Evaluation

As D1R agonism has significant implications in the treatment of cognitive deficits, we sought to develop novel D1R PAMs, through the derigidification of BMS D1R PAM hit compound. While we were able to synthesize derigidified analogs of the BMS hit compound, derigidification did not produce active D1R ligands