Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017)

Reduction in dietary vitamin B6 intakes is associated with increased relative risk of diseases such as cancer, atherosclerosis, and cognitive dysfunction. All forms of dietary vitamin B6 are converted to pyridoxal 5'-phosphate (PLP), that is needed for the proper function of a spectrum of metabolic pathways needed to maintain health. To better understand vitamin B6 homeostasis, it is important to identify lifestyle factors that influence vitamin B6 intake and plasma PLP concentration in the UK population. Therefore, this research has assessed vitamin B6 intake and PLP concentrations as a marker of vitamin B6 status among the UK adult (≥ 19 years) population. This study was carried out using a cross-sectional analysis of the National Diet and Nutrition Survey Rolling Programme (NDNS) (2008 - 2017). The impacts of lifestyle factors including type of diet, smoking, alcohol consumption, and commonly used medications grouped by therapeutic usage, were determined and data analysed using IBM SPSS®. Results are expressed as medians (25th to 75th percentiles), with P values ≤ 0.05 considered statistically significant. Among UK adults, the median intakes of total population of dietary vitamin B6 met the RNI and median plasma PLP concentrations were above the cut-off of vitamin B6 deficiency, however, we found association between reduction in vitamin B6 intake and plasma PLP concentration and age group (P<0.001). Smokers had significantly lower plasma PLP concentrations than the non-smokers (P<0.001). Moreover, regression analysis showed some commonly used medications were associated with plasma PLP levels reduction (P