Receptors are important drug targets for the pharmaceutical industry, since they are involved in many illnesses. Nuclear receptors are a subset of receptors that control a variety of physiological events, by expression of genes from DNA. One of the nuclear receptors, the androgen receptor, is a steroid binding receptor that controls a variety of regulatory and development functions in the body. It is also the cause of some types of cancer, so the inhibition of this receptor is crucial. One of the processes studied to inhibit the function of the receptor is to see if an allosteric ligand, TRIAC, can bind to the BF-3 site, therefore inducing a change in the receptor and release of the endogenous ligand (DHT) before there is recruitment of oth...
Os receptores nucleares constituem uma superfamília de fatores de transcrição regulados pela interaç...
A member of the nuclear receptor superfamily, the estrogen receptor (ER) is a ligand-regulated trans...
The androgen receptor (AR) is a ligand-activated transcription factor that plays a crucial role in t...
Receptors are important drug targets for the pharmaceutical industry, since they are involved in man...
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, e...
Nuclear receptors are ligand-activated transcription factors that play significant roles in various ...
Androgen receptor (AR), as a member of the nuclear receptor (NR) superfamily, regulates the gene tra...
textabstractThe steroid hormones testosterone and 5a-dihydrotestosterone (androgens) control the dev...
Testosterone (T) and dihydrotestosterone (DHT) are natural ligands for the androgen receptor (AR), a...
SummaryThe pharmacological activity of different nuclear receptor ligands is reflected by their impa...
Nuclear receptors (NRs) are a large family of mammalian transcription factors that have the particu...
IN ENGLISH LANGUAGE Candidate: Mgr. Alejandro Carazo Fernández Supervisor: Prof. PharmDr. Petr Pávek...
This work focuses on steroid receptors, including the androgen receptor (AR), the estrogen receptors...
Receptores de androgênio (AR) são membros da superfamília de receptores nucleares que incluem os rec...
The androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype mai...
Os receptores nucleares constituem uma superfamília de fatores de transcrição regulados pela interaç...
A member of the nuclear receptor superfamily, the estrogen receptor (ER) is a ligand-regulated trans...
The androgen receptor (AR) is a ligand-activated transcription factor that plays a crucial role in t...
Receptors are important drug targets for the pharmaceutical industry, since they are involved in man...
We have previously identified a family of novel androgen receptor (AR) ligands that, upon binding, e...
Nuclear receptors are ligand-activated transcription factors that play significant roles in various ...
Androgen receptor (AR), as a member of the nuclear receptor (NR) superfamily, regulates the gene tra...
textabstractThe steroid hormones testosterone and 5a-dihydrotestosterone (androgens) control the dev...
Testosterone (T) and dihydrotestosterone (DHT) are natural ligands for the androgen receptor (AR), a...
SummaryThe pharmacological activity of different nuclear receptor ligands is reflected by their impa...
Nuclear receptors (NRs) are a large family of mammalian transcription factors that have the particu...
IN ENGLISH LANGUAGE Candidate: Mgr. Alejandro Carazo Fernández Supervisor: Prof. PharmDr. Petr Pávek...
This work focuses on steroid receptors, including the androgen receptor (AR), the estrogen receptors...
Receptores de androgênio (AR) são membros da superfamília de receptores nucleares que incluem os rec...
The androgen receptor (AR) plays important roles in gene expression regulation, sexual phenotype mai...
Os receptores nucleares constituem uma superfamília de fatores de transcrição regulados pela interaç...
A member of the nuclear receptor superfamily, the estrogen receptor (ER) is a ligand-regulated trans...
The androgen receptor (AR) is a ligand-activated transcription factor that plays a crucial role in t...