Patients with Alzheimer's disease dementia show partially preserved parietal 'hubs' modeled from resting-state alpha electroencephalographic rhythms
- Lopez, Susanna
- Del Percio, Claudio
- Lizio, Roberta
- Noce, Giuseppe
- Padovani, Alessandro
- Nobili, Flavio
- Arnaldi, Dario
- Famà, Francesco
- Moretti, Davide V
- Cagnin, Annachiara
- Koch, Giacomo
- Benussi, Alberto
- Onofrj, Marco
- Borroni, Barbara
- Soricelli, Andrea
- Ferri, Raffaele
- Buttinelli, Carla
- Giubilei, Franco
- Güntekin, Bahar
- Yener, Görsev
- Stocchi, Fabrizio
- Vacca, Laura
- Bonanni, Laura
- Babiloni, Claudio
DOIAbstract
Introduction: Graph theory models a network by its nodes (the fundamental unit by which graphs are formed) and connections. 'Degree' hubs reflect node centrality (the connection rate), while 'connector' hubs are those linked to several clusters of nodes (mainly long-range connections). Methods: Here, we compared hubs modeled from measures of interdependencies of between-electrode resting-state eyes-closed electroencephalography (rsEEG) rhythms in normal elderly (Nold) and Alzheimer's disease dementia (ADD) participants. At least 5 min of rsEEG was recorded and analyzed. As ADD is considered a 'network disease' and is typically associated with abnormal rsEEG delta (<4 Hz) and alpha rhythms (8-12 Hz) over associative posterior areas, we teste...
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