Phagocyte-specific S100 proteins and high-sensitivity C reactive protein as biomarkers for a risk-adapted treatment to maintain remission in juvenile idiopathic arthritis: a comparative study
- Roth, Johannes
- Saurenmann, Traudel
- Uziel, Yosef
- Vesely, Richard
- Teresa Apaz, Maria
- Kuester, Rolf-Michael
- Rua Elorduy, Maria Jesus
- Burgos-Vargas, Ruben
- Ioseliani, Maka
- Magni-Manzoni, Silvia
- Anton, Jordi
- Balogh, Zsolt
- Masi, Massimo
- Toppino, Claudia
- Len, Claudio
- Hagelberg, Stefan
- Mazur-Zielinska, Henryka
- Tauber, Tsivia
- Harjacek, Miroslav
- Mihaylova, Dimitrina
- Ruperto, Nicolino
- Martini, Alberto
- Foell, Dirk
- Wedderburn, Lucy
- Wittkowski, Helmut
- Wulffraat, Nico
- Frosch, Michael
- Stanevicha, Valda
- Holzinger, Dirk
- Unsal, Erbil
- Minden, Kirsten
- Gerss, Joachim
Publication date
December 2012
DOIAbstract
Objectives Juvenile idiopathic arthritis (JIA) is a chronic inflammatory joint disease affecting children. Even if remission is successfully induced, about half of the patients experience a relapse after stopping anti-inflammatory therapy. The present study investigated whether patients with JIA at risk of relapse can be identified by biomarkers even if clinical signs of disease activity are absent