Systolic pulmonary artery pressure and echocardiographic measurements in patients with euthyroid Hashimoto's thyroiditis

Background: The aim of this study was to investigate systolic pulmonary artery pressure (SPAP) and echocardiographic findings in patients with euthyroid Hashimoto's thyroiditis (HT). Methods: Thirty (8 male, 22 female, mean age 47.4 +/- 10.5 yr) consecutive patients with euthyroid HT and 30 (9 male, 21 female, mean age 46.4 +/- 10.7 yr) healthy controls were included in the study. Transthoracic echocardiography was performed for all patients and levels of thyroid hormones, thyroid autoantibodies, glucose, insulin, urea, and creatinine were compared. Results: There were no significant differences in sex, age, body mass index, serum free T-4, serum TSH, lipid profiles between patients and controls. Mean SPAP in patients with euthyroid HT were significantly higher than in controls (31.6 +/- 5.0 vs 25.6 +/- 4.5 mmHg, p=0.005). Late diastolic trans-mitral velocity and isovolumic relaxation time were also significantly higher in patients in comparison to controls. In addition, euthyroid HT patients with tricuspid or mitral regurgitation had a higher grade. Correlation between SPAP and antithyroid antibodies and TSH, however, was not significant in this population. Conclusions: Pulmonary arterial pressure is higher in patients with euthyroid HT. There may be a relationship between elevated pulmonary arterial pressure and autoimmune thyroid disease independent from thyroid function status. However, further investigations are needed to determine the exact mechanism of association between autoimmune thyroid diseases and pulmonary hypertension. (J. Endocrinol. Invest. 32: 530-532, 2009) (C) 2009, Editrice Kurti