Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune-complex nephritis
- Saglam, Funda
- ÇAVDAR, ZAHİDE
- Celik, Ali
- Tayfur, Devrim
- Camsari, Taner
- KOLATAN, HATİCE EFSUN
- SARIOĞLU, SÜLEN
- OKTAY, GÜLGÜN
- YILMAZ, OSMAN
Publication date
August 2010
DOIAbstract
Aim: Renal expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) contribute to the development of tubulointerstitial fibrosis characteristic of progressive forms of primary glomerulonephritis (GN). The aim of this study was to investigate the therapeutic effect of MMP inhibitor, doxycycline, administration in an experimental rat model of immune-complex nephritis (ICN)
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