Assessment of Citrullinated Myelin by H-1-MR Spectroscopy in Early-Onset Multiple Sclerosis

BACKGROUND AND PURPOSE: Myelin instability and citrullinated myelin basic protein have been demonstrated in the brains of patients with chronic and fulminating forms of multiple sclerosis (MS). Our aim was to trace citrulline in the brains of patients with early-onset MS by using proton MR spectroscopy (H-1-MR spectroscopy)