Autoimmune polyglandular endocrinopathy and anterior hypophysitis in a 14 year-old girl presenting with delated puberty

Dündar, B.
Pinar Cemeroglu, A.
BÖBER, ECE
Büyükgebiz, A.

Publication date

August 2001

Abstract

We report a 14 year-old peripubertal girl who presented at our clinic with the primary complaint of delayed puberty. She was asymptomatic except for vague complaints of fatigue. Physical examination was significant for mucosal hyperpigmentation and lack of secondary sexual characteristics. Laboratory evaluation revealed a morning cortisol concentration of <0.1 μg/dl (normal range [n.r.]: 4.3-22.4 μg/dl) and a simultaneous ACTH concentration of 2 pg/ml (n.r. 25-62 pg /ml); FSH 66.8 IU/l (n.r. for age: 1-12.8 IU/l); LH 41.1 IU/l (n.r. for age: 1-12 IU/l); E2 38 pg/ml (n.r. for age: 7-60 pg/ml). She had a flat cortisol response to an ACTH stimulation test. MRI of the pituitary gland failed to reveal a lesion. Plasma renin activity, thyroid fun...