Every year about two million new cases of colorectal cancer are diagnosed worldwide, with a mortality close to 50%. Screening and early detection are key to increase the five-year survival rate, which goes above 90% when the cancer is detected at stage 1 and drops below 10% at stage 4. Non-invasive screening, such as FIT (Faecal Immunochemical Test), is adopted in many national bowel screening programs to detect cancer at early stage. Colonoscopy remains the ultimate step to have an optical inspection of the colonic wall and to remove polyps, which may eventually become cancerous. However, this procedure is not well accepted by patients due to pain and discomfort. The pressure of the colonoscope against the colonic wall can damage the mucos...