Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in growth, development and regulation of the immune system. TGF-β itself controls immune homeostasis and inflammation, including conversion of naïve CD4 + T cells into Foxp3 + regulatory T cells (Tregs) in the presence of interleukin-2 and T-cell receptor ligands. The helminth parasite Heligmosomoides polygyrus exploits this pathway through a structurally novel TGF-β mimic (Hp-TGM), which binds to mammalian TGF-β receptors and induces Tregs. Here, we performed detailed comparisons of Hp-TGM with mammalian TGF-β. Compared with TGF-β, Hp-TGM induced greater numbers of Foxp3 + Tregs (iTregs), with more intense Foxp3 expression. Both ligands upregula...
Immune homeostasis in the intestine is tightly controlled by FOXP3 + regulatory T cells (Tregs), def...
Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defe...
We recently reported the discovery of a new parasite-derived protein that functionally mimics the im...
Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in g...
Transforming growth factor‐beta (TGF‐β) family proteins mediate many vital biological functions in g...
Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in g...
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activat...
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activat...
Immune homeostasis in the intestine is tightly controlled by FOXP3 + regulatory T cells (Tregs), def...
Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defe...
We recently reported the discovery of a new parasite-derived protein that functionally mimics the im...
Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in g...
Transforming growth factor‐beta (TGF‐β) family proteins mediate many vital biological functions in g...
Transforming growth factor-beta (TGF-β) family proteins mediate many vital biological functions in g...
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activat...
Helminth parasites defy immune exclusion through sophisticated evasion mechanisms, including activat...
Immune homeostasis in the intestine is tightly controlled by FOXP3 + regulatory T cells (Tregs), def...
Immune homeostasis in the intestine is tightly controlled by FOXP3+ regulatory T cells (Tregs), defe...
We recently reported the discovery of a new parasite-derived protein that functionally mimics the im...