In order for cells to divide, they must replicate their chromosomes precisely once. This replication is performed by a number of proteins that act together to form a replication fork. The major control over DNA replication occurs at replication origins, the sites where active replication forks are initiated. In the yeast S. cerevisiae, origins have been identified as ARSs which possess a defined DNA sequence. These ARSs are recognized by specific proteins including ORC and ABF1. The elements which define origins in higher eukaryotes have not yet been identified. The temporal sequence in which origins fire is dependent on both the chromosomal location of the origin and the transcriptional activity of the dividing cell, with euchromatin and a...
In each cell cycle the complex structure of the chromosome must be replicated accurately. In the las...
Eukaryotic DNA replication origins are selected in G1-phase when the origin recognition complex (ORC...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.Includes bibliographi...
In order for cells to divide, they must replicate their chromosomes precisely once. This replication...
In order for cells to divide, they must replicate their chromosomes precisely once. This replication...
Eukaryotic DNA replication is regulated by the formation of protein complexes over the initiator pro...
Our primary goal has been to understand how chromosomes are duplicated during the cell division cycl...
The replication of DNA in the eukaryotic cell cycle is one of the most highly regulated events in ce...
While many of the proteins involved in the initiation of DNA replication are conserved between yeast...
<p>The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance fo...
AbstractRecent results have provided substantial new insights into how the initiation of DNA replica...
The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance for t...
In Sacchromyces cerevisiae, it is well known that bidirectional replication initiates at sequence sp...
AbstractDNA replication is precisely regulated in time and space, thereby safeguarding genomic integ...
In each cell cycle the complex structure of the chromosome must be replicated accurately. In the las...
In each cell cycle the complex structure of the chromosome must be replicated accurately. In the las...
Eukaryotic DNA replication origins are selected in G1-phase when the origin recognition complex (ORC...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.Includes bibliographi...
In order for cells to divide, they must replicate their chromosomes precisely once. This replication...
In order for cells to divide, they must replicate their chromosomes precisely once. This replication...
Eukaryotic DNA replication is regulated by the formation of protein complexes over the initiator pro...
Our primary goal has been to understand how chromosomes are duplicated during the cell division cycl...
The replication of DNA in the eukaryotic cell cycle is one of the most highly regulated events in ce...
While many of the proteins involved in the initiation of DNA replication are conserved between yeast...
<p>The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance fo...
AbstractRecent results have provided substantial new insights into how the initiation of DNA replica...
The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance for t...
In Sacchromyces cerevisiae, it is well known that bidirectional replication initiates at sequence sp...
AbstractDNA replication is precisely regulated in time and space, thereby safeguarding genomic integ...
In each cell cycle the complex structure of the chromosome must be replicated accurately. In the las...
In each cell cycle the complex structure of the chromosome must be replicated accurately. In the las...
Eukaryotic DNA replication origins are selected in G1-phase when the origin recognition complex (ORC...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2006.Includes bibliographi...