The lens is an avascular tissue, separated from the aqueous and vitreous humors by its own extracellular matrix, the lens capsule. Here we demonstrate that the lens capsule is a source of essential survival factors for lens epithelial cells. Primary and immortalized lens epithelial cells survive in low levels of serum and are resistant to staurosporine-induced apoptosis when they remain in contact with the lens capsule. Physical contact with the capsule is required for maximal resistance to stress. The lens capsule is also a source of soluble factors including fibroblast growth factor 2 (FGF-2) and perlecan, an extracellular matrix component that enhances FGF-2 activity. Matrix metalloproteinase 2 (MMP-2) inhibition as well as MMP-2 pretrea...
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate ...
Summary: Emerging evidence challenges the lens as an immune-privileged organ. Here, we provide a dir...
AIM: To investigate the effects of Msx2 on lens epithelium cell cycle, and evaluate the changes of t...
The lens is an avascular tissue, separated from the aqueous and vitreous humors by its own extracell...
The lens is an avascular tissue, separated from the aqueous and vitreous humors by its own extracell...
Posterior capsular opacification is the main complication of cataract surgery and results from the p...
AbstractFibroblast growth factors play a key role in regulating lens epithelial cell proliferation a...
Fibroblast growth factors play a key role in regulating lens epithelial cell proliferation and diffe...
The eye lens consists of epithelial cells, fibre cells and an outer capsule. The epithelium plays a ...
Multiple studies have clearly identified the growth factors that promote lens epithelial cell differ...
There is increasing evidence implicating Transforming growth factor ß (TGF-ß) in pathological states...
Transforming growth factor beta (TGFβ), a potent inducer of cell transdifferentiation, is heavily im...
Transforming growth factor (TGF) β and fibroblast growth factor (FGF) 2 are related to the deve...
Maintaining lens integrity is a lifetime ambition of the lens. However, if this integrity is breache...
Epithelial-mesenchymal transition (EMT) is associated with fibrotic diseases in the lens, such as an...
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate ...
Summary: Emerging evidence challenges the lens as an immune-privileged organ. Here, we provide a dir...
AIM: To investigate the effects of Msx2 on lens epithelium cell cycle, and evaluate the changes of t...
The lens is an avascular tissue, separated from the aqueous and vitreous humors by its own extracell...
The lens is an avascular tissue, separated from the aqueous and vitreous humors by its own extracell...
Posterior capsular opacification is the main complication of cataract surgery and results from the p...
AbstractFibroblast growth factors play a key role in regulating lens epithelial cell proliferation a...
Fibroblast growth factors play a key role in regulating lens epithelial cell proliferation and diffe...
The eye lens consists of epithelial cells, fibre cells and an outer capsule. The epithelium plays a ...
Multiple studies have clearly identified the growth factors that promote lens epithelial cell differ...
There is increasing evidence implicating Transforming growth factor ß (TGF-ß) in pathological states...
Transforming growth factor beta (TGFβ), a potent inducer of cell transdifferentiation, is heavily im...
Transforming growth factor (TGF) β and fibroblast growth factor (FGF) 2 are related to the deve...
Maintaining lens integrity is a lifetime ambition of the lens. However, if this integrity is breache...
Epithelial-mesenchymal transition (EMT) is associated with fibrotic diseases in the lens, such as an...
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate ...
Summary: Emerging evidence challenges the lens as an immune-privileged organ. Here, we provide a dir...
AIM: To investigate the effects of Msx2 on lens epithelium cell cycle, and evaluate the changes of t...