Add to ORKGIn view of the controversy regarding genetic variation at the fibrinogen loci and plasma fibrinogen levels, we have analysed DNA polymorphisms at the alpha (TaqI), beta (BclI and HaeIII), and gamma (KpnI/SacI) fibrinogen loci in 247 subjects whose plasma fibrinogen was determined by clotting and nephelometric assays. Strong linkage disequilibrium was found between the alpha/TaqI and gamma/KpnI/SacI markers and between the beta/BclI and beta/HaeIII markers. A lesser association was found between the alpha/ TaqI and beta/BclI loci, beta/BclI and gamma/KpnI/SacI markers, alpha/ TaqI and beta/HaeIII markers, and the gamma/KpnI/SacI and beta/HaeIII markers. This is consistent with the known physical order of these loci and suggests a relative ex...
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the m...
There is conflicting evidence about the influence of fibrinogen genotype on plasma fibrinogen concen...
Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify co...
In view of the controversy regarding genetic variation at the fibrinogen loci and plasma fibrinogen ...
Three previously described polymorphisms of the α- and β-fibrinogen genes detectable with the restri...
Fibrinogen is an acute phase reactant increased during inflammation; it is also affected by diabetes...
Four novel polymorphisms were identified in the fibrinogen gene cluster. Three of them were localize...
Genome-wide association studies have previously identified 23 genetic loci associated with circulati...
Genome-wide association studies have previously identified 23 genetic loci associated with circulati...
Genome-wide association studies have previously identified 23 genetic loci associated with circulati...
In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms...
Abstract—Plasma fibrinogen is a major risk factor for coronary heart disease, stroke, and peripheral...
Introduction: Circulating levels of fibrinogen are associated with atherosclerosis and predict futur...
Elevated plasma levels of fibrinogen have been associated with an increased risk of peripheral vascu...
This study was designed to investigate whether single nucleotide polymorphisms (SNPs) and haplotypes...
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the m...
There is conflicting evidence about the influence of fibrinogen genotype on plasma fibrinogen concen...
Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify co...
In view of the controversy regarding genetic variation at the fibrinogen loci and plasma fibrinogen ...
Three previously described polymorphisms of the α- and β-fibrinogen genes detectable with the restri...
Fibrinogen is an acute phase reactant increased during inflammation; it is also affected by diabetes...
Four novel polymorphisms were identified in the fibrinogen gene cluster. Three of them were localize...
Genome-wide association studies have previously identified 23 genetic loci associated with circulati...
Genome-wide association studies have previously identified 23 genetic loci associated with circulati...
Genome-wide association studies have previously identified 23 genetic loci associated with circulati...
In the Study of Myocardial Infarctions Leiden, we investigated the prevalence of three polymorphisms...
Abstract—Plasma fibrinogen is a major risk factor for coronary heart disease, stroke, and peripheral...
Introduction: Circulating levels of fibrinogen are associated with atherosclerosis and predict futur...
Elevated plasma levels of fibrinogen have been associated with an increased risk of peripheral vascu...
This study was designed to investigate whether single nucleotide polymorphisms (SNPs) and haplotypes...
Elevated plasma fibrinogen levels represent an increased risk for cardiovascular diseased, but the m...
There is conflicting evidence about the influence of fibrinogen genotype on plasma fibrinogen concen...
Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify co...