Recent studies have suggested increased plasticity of differentiated cells within the intestine to act both as intestinal stem cells (ISCs) and tumour-initiating cells. However, little is known of the processes that regulate this plasticity. Our previous work has shown that activating mutations of Kras or the NF-κB pathway can drive dedifferentiation of intestinal cells lacking Apc. To investigate this process further, we profiled both cells undergoing dedifferentiation in vitro and tumours generated from these cells in vivo by gene expression analysis. Remarkably, no clear differences were observed in the tumours; however, during dedifferentiation in vitro we found a marked upregulation of TGFβ signalling, a pathway commonly mutated in col...
Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion ...
SummaryA large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-β ...
signaling pathways serve to maintain homeostasis in the normal intestinal epithelium. This state is ...
Recent studies have suggested increased plasticity of differentiated cells within the intestine to a...
SummaryCell-type plasticity within a tumor has recently been suggested to cause a bidirectional conv...
The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial....
Colon cancer cells frequently carry mutations that activate the β-catenin and mitogen-activated prot...
Genetic alterations in the TGFβ signaling pathway in combination with oncogenic alterations lead to ...
Human colorectal cancer (CRC) is one of the most common types of cancer. Aberrant activation of the...
The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a d...
Colorectal cancer (CRC) is one of the leading causes of cancer related mortality in Western countrie...
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profil...
[Figure: see text].Somatic mutations in APC or CTNNB1 genes lead to aberrant Wnt signaling and color...
Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppre...
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and i...
Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion ...
SummaryA large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-β ...
signaling pathways serve to maintain homeostasis in the normal intestinal epithelium. This state is ...
Recent studies have suggested increased plasticity of differentiated cells within the intestine to a...
SummaryCell-type plasticity within a tumor has recently been suggested to cause a bidirectional conv...
The pro-tumourigenic role of epithelial TGFβ signalling in colorectal cancer (CRC) is controversial....
Colon cancer cells frequently carry mutations that activate the β-catenin and mitogen-activated prot...
Genetic alterations in the TGFβ signaling pathway in combination with oncogenic alterations lead to ...
Human colorectal cancer (CRC) is one of the most common types of cancer. Aberrant activation of the...
The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a d...
Colorectal cancer (CRC) is one of the leading causes of cancer related mortality in Western countrie...
Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profil...
[Figure: see text].Somatic mutations in APC or CTNNB1 genes lead to aberrant Wnt signaling and color...
Transforming growth factor-beta (TGF-beta) is a pluripotent cytokine that can have both tumor suppre...
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan biology, and i...
Cell-type plasticity within a tumor has recently been suggested to cause a bidirectional conversion ...
SummaryA large proportion of colorectal cancers (CRCs) display mutational inactivation of the TGF-β ...
signaling pathways serve to maintain homeostasis in the normal intestinal epithelium. This state is ...