When DNA replication is slowed down, normally dormant replication origins are activated. Recent work demonstrates that cells adapt by changing the organization of chromatin loops and maintaining the new pattern of origin use in subsequent cell cycles.</p
<div><p>Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of o...
Replication origins are 'licensed' for a single initiation event before entry into S phase; however,...
Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances...
When DNA replication is slowed down, normally dormant replication origins are activated. Recent work...
Genome stability requires tight regulation of DNA replication to ensure that the entire genome of th...
Many replication origins that are licensed by loading MCM2-7 complexes in G1 are not normally used. ...
International audienceEukaryotic DNA replication is regulated by conserved mechanisms that bring abo...
AbstractDNA replication is precisely regulated in time and space, thereby safeguarding genomic integ...
In late mitosis and early G1, Mcm2-7 complexes are loaded onto DNA to license replication origins fo...
International audienceDuring each cell cycle, thousands of DNA replication origins are activated in ...
Complete and accurate DNA replication requires the progression of replication forks through DNA dama...
International audienceTo unveil the still-elusive nature of metazoan replication origins, we identif...
The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance for t...
In order for cells to divide, they must replicate their chromosomes precisely once. This replication...
<div><p>Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of o...
Replication origins are 'licensed' for a single initiation event before entry into S phase; however,...
Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances...
When DNA replication is slowed down, normally dormant replication origins are activated. Recent work...
Genome stability requires tight regulation of DNA replication to ensure that the entire genome of th...
Many replication origins that are licensed by loading MCM2-7 complexes in G1 are not normally used. ...
International audienceEukaryotic DNA replication is regulated by conserved mechanisms that bring abo...
AbstractDNA replication is precisely regulated in time and space, thereby safeguarding genomic integ...
In late mitosis and early G1, Mcm2-7 complexes are loaded onto DNA to license replication origins fo...
International audienceDuring each cell cycle, thousands of DNA replication origins are activated in ...
Complete and accurate DNA replication requires the progression of replication forks through DNA dama...
International audienceTo unveil the still-elusive nature of metazoan replication origins, we identif...
The accurate and timely replication of eukaryotic DNA during S-phase is of critical importance for t...
In order for cells to divide, they must replicate their chromosomes precisely once. This replication...
<div><p>Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of o...
Replication origins are 'licensed' for a single initiation event before entry into S phase; however,...
Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances...
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