It is important to identify the true substrates of protein kinases because this illuminates the primary function of any kinase. Here, we used bioinformatics and biochemical validation to identify novel brain substrates of the Ser/Thr kinase glycogen synthase kinase 3 (GSK3). Briefly, sequence databases were searched for proteins containing a conserved GSK3 phosphorylation consensus sequence ((S/T)PXX(S/T)P or (S/T)PXXX(S/T)P), as well as other criteria of interest (e.g. brain proteins). Importantly, candidates were highlighted if they had previously been reported to be phosphorylated at these sites by large-scale phosphoproteomic studies. These criteria identified the brain-enriched cytoskeleton-associated protein beta-adducin as a likely s...
The chapter provides a short summary of the structure, substrate specificity, functions, and regulat...
Recently studies have shown that glycogen synthase kinase- 3 (GSK-3) is essential for chemotaxis in ...
As a constitutively active kinase, glycogen synthase kinase 3 (GSK3) is a kinase which regulates bod...
It is important to identify the true substrates of protein kinases because this illuminates the prim...
P>Mammalian glycogen synthase kinase-3 (GSK3) is generated from two genes, GSK3 alpha and GSK3 be...
Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3 (GSK3) is no...
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that ac...
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that exists as two isoforms, α and β...
Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of mult...
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that ac...
Glycogen synthase kinase 3 beta (GSK-3β) is an evolutionarily conserved serine-threonine kinase dysr...
Glycogen synthase kinase-3 (GSK3) is a highly conserved multifunctional kinase that regulates many c...
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a part in a number of phys...
Glycogen synthase kinase-3beta (GSK-3beta) has been demonstrated to play a critical role in a divers...
Human glycogen synthase kinase-3α (GSK-3α) is a serine/threonine kinase that phosphorylates a variet...
The chapter provides a short summary of the structure, substrate specificity, functions, and regulat...
Recently studies have shown that glycogen synthase kinase- 3 (GSK-3) is essential for chemotaxis in ...
As a constitutively active kinase, glycogen synthase kinase 3 (GSK3) is a kinase which regulates bod...
It is important to identify the true substrates of protein kinases because this illuminates the prim...
P>Mammalian glycogen synthase kinase-3 (GSK3) is generated from two genes, GSK3 alpha and GSK3 be...
Identified originally as a regulator of glycogen metabolism, glycogen synthase kinase-3 (GSK3) is no...
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that ac...
Glycogen synthase kinase-3 (GSK-3) is a serine-threonine kinase that exists as two isoforms, α and β...
Glycogen synthase kinase-3 (GSK-3) is a constitutively active kinase, involved in regulation of mult...
Glycogen Synthase Kinase-3 (GSK-3) is a constitutively active, ubiquitously expressed kinase that ac...
Glycogen synthase kinase 3 beta (GSK-3β) is an evolutionarily conserved serine-threonine kinase dysr...
Glycogen synthase kinase-3 (GSK3) is a highly conserved multifunctional kinase that regulates many c...
Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that plays a part in a number of phys...
Glycogen synthase kinase-3beta (GSK-3beta) has been demonstrated to play a critical role in a divers...
Human glycogen synthase kinase-3α (GSK-3α) is a serine/threonine kinase that phosphorylates a variet...
The chapter provides a short summary of the structure, substrate specificity, functions, and regulat...
Recently studies have shown that glycogen synthase kinase- 3 (GSK-3) is essential for chemotaxis in ...
As a constitutively active kinase, glycogen synthase kinase 3 (GSK3) is a kinase which regulates bod...