Frequency of false-positive FISH 1p/19q codeletion in adult diffuse astrocytic gliomas
- Ball, Matthew K
- Kollmeyer, Thomas M
- Praska, Corinne E
- McKenna, Michelle L
- Giannini, Caterina
- Raghunathan, Aditya
- Jentoft, Mark E
- Lachance, Daniel H
- Kipp, Benjamin R
- Jenkins, Robert B
- Ida, Cristiane M
DOIAbstract
Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. Codeletion of 1p/19q traditionally evaluated by fluorescence in situ hybridization (FISH) cannot distinguish partial from whole-arm 1p/19q codeletion. Partial 1p/19q codeletion called positive by FISH is diagnostically a "false-positive" result. Chromosomal microarray (CMA) discriminates partial from whole-arm 1p/19q codeletion. Herein, we aimed to estimate the frequency of partial 1p/19q codeletion that would lead to a false-positive FISH result
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