One of the streams in the early development of set theory was an attempt to use mereology, a formal theory of parthood, as a foundational tool. The first such attempt is due to a Polish logician, Stanisław Leśniewski (1886–1939). The attempt failed, but there is another, prima facie more promising attempt by Jerzy Słupecki (1904–1987), who employed his generalized mereology to build mereological foundations for type theory. In this paper I (1) situate Leśniewski's attempt in the development of set theory, (2) describe and evaluate Leśniewski's approach, (3) describe Słupecki's strategy without unnecessary technical details, and (4) evaluate it with a rather negative outcome. The issues discussed go beyond merely historical interests due to ...