Enantioselective separations by capillary gas chromatography on derivatized cyclodextrins : III. Separation of some racemic 2,2-dialkyl-4-alkoxycarbonyl-1,3-dioxolane derivatives on 2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl-β-cyclodextrin and 2,3-di-O-acetyl-6-O-tert-butyldimethylsilyl-γ-cyclodextrins

The enantioseparation of a set of 2,2-dialkyl-4-alkoxycarbonyl-1,3-dioxolane derivatives, which are important intermediates in the total synthesis of biologically active compounds, was studied by means of capillary gas chromatography (cGC). The chromatographic results, obtained on columns coated with 2,3-di-O-acetyl-6-O-tert. -butyldimethylsilyl-beta- and -gamma-cyclodextrins are reported. Most of the compounds could be separated with a resolution greater than 1.42. Considerations concerning the interaction mechanism are presented