Evaluation of [11C]thymidine for measurement of cell proliferation in fast dividing tissues

The Purpose of this study was to investigate the possibility of using [C-11]thymidine as a tumor marker for positron emission tomography studies. Biodistribution studies were set up to investigate the in vivo behavior of [C-11]thymidine. Simultaneously, the DNA incorporation in fast dividing tissues and catabolism was studied. Our results confirm that [C-11]thymidine can be used for detection of cell proliferation by positron emission tomography. As such, it can produce supplementary information in cancer research