Leishmaniasis is a major tropical disease that can present with cutaneous, mucocutaneous, or visceral manifestation and affects millions of individuals, causing substantial morbidity and mortality in-third-world countries. The development of a Th1-adaptive immune response is associated with resistance to developing Leishmania major (L. major) infection. Inflammasomes are key components of the innate immune system that contribute to host defense against bacterial and viral pathogens; however, their role in regulating adaptive immunity during infection with protozoan parasites is less studied. Here, we demonstrated that the NLRP3 inflammasome balances Th1/Th2 responses during leishmaniasis. Mice lacking the inflammasome components NLRP3, ASC,...
TNF-negative C57BL/6 (B6.TNF−/−) mice are highly susceptible to Leishmania (L.) major infection and ...
Abstract Background Chronic inflammation activated by macrophage innate pathogen recognition recepto...
Recent studies have shown that a cytoplasmic virus called Leishmaniavirus (LRV) is present in some L...
The obligate intracellular protozoan parasite Leishmania major is transmitted by sandfly vectors and...
Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a disease tha...
Infection of C57BL/6 mice with most Leishmania major strains results in a healing lesion and clearan...
<div><p>Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in s...
Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized ...
Leishmaniasis represents a severe, increasing, public health problem. The perspective of its control...
Author Summary Leishmaniasis is a disease induced by a protozoan parasite and transmitted by the san...
Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized ...
BACKGROUND: Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwid...
Poster: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Background: Lei...
Leishmaniasis is the spectrum of diseases that are caused by single cell protozoan parasites of Leis...
Classically activated macrophages produce high levels of IL-12 and moderate levels of IL-10. When I...
TNF-negative C57BL/6 (B6.TNF−/−) mice are highly susceptible to Leishmania (L.) major infection and ...
Abstract Background Chronic inflammation activated by macrophage innate pathogen recognition recepto...
Recent studies have shown that a cytoplasmic virus called Leishmaniavirus (LRV) is present in some L...
The obligate intracellular protozoan parasite Leishmania major is transmitted by sandfly vectors and...
Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a disease tha...
Infection of C57BL/6 mice with most Leishmania major strains results in a healing lesion and clearan...
<div><p>Deregulated CD8+ T cell cytotoxicity plays a central role in enhancing disease severity in s...
Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized ...
Leishmaniasis represents a severe, increasing, public health problem. The perspective of its control...
Author Summary Leishmaniasis is a disease induced by a protozoan parasite and transmitted by the san...
Infections with Leishmania parasites of the Leishmania Viannia subgenus give rise to both localized ...
BACKGROUND: Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwid...
Poster: 1st Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Background: Lei...
Leishmaniasis is the spectrum of diseases that are caused by single cell protozoan parasites of Leis...
Classically activated macrophages produce high levels of IL-12 and moderate levels of IL-10. When I...
TNF-negative C57BL/6 (B6.TNF−/−) mice are highly susceptible to Leishmania (L.) major infection and ...
Abstract Background Chronic inflammation activated by macrophage innate pathogen recognition recepto...
Recent studies have shown that a cytoplasmic virus called Leishmaniavirus (LRV) is present in some L...