BACKGROUND/AIMS: It has been proposed that, in acute liver failure, skeletal muscle adapts to become the principle organ responsible for removal of blood-borne ammonia by increasing glutamine synthesis, a reaction that is catalyzed by the cytosolic ATP-dependent enzyme glutamine synthetase. To address this issue, glutamine synthetase expression and activities were measured in skeletal muscle of rats with acute liver failure resulting from hepatic devascularization. METHODS: Glutamine synthetase protein and gene expression were investigated using immunoblotting and semi-quantitative RT-PCR analysis. Glutamine synthetase activity and glutamine de novo synthesis were measured using, respectively, a standard enzymatic assay and [13C]-nuclear ma...
Interorgan ammonia metabolism in liver failure. Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jal...
The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) o...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopa...
Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopa...
Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopa...
Studies from the last decades indicate that increased levels of ammonia contribute to muscle wasting...
Ammonia reduction is the target for therapy of hepatic encephalopathy, but lack of quantitative data...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...
© 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society Key points: Hyperammo...
Interorgan ammonia metabolism in liver failure.Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jala...
Interorgan ammonia metabolism in liver failure.Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jala...
Interorgan ammonia metabolism in liver failure. Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jal...
The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) o...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopa...
Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopa...
Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopa...
Studies from the last decades indicate that increased levels of ammonia contribute to muscle wasting...
Ammonia reduction is the target for therapy of hepatic encephalopathy, but lack of quantitative data...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...
© 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society Key points: Hyperammo...
Interorgan ammonia metabolism in liver failure.Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jala...
Interorgan ammonia metabolism in liver failure.Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jala...
Interorgan ammonia metabolism in liver failure. Olde Damink SW, Deutz NE, Dejong CH, Soeters PB, Jal...
The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) o...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...