Ferroportin (Fpn) is the only known iron exporter in humans and is essential for maintaining iron homeostasis. Fpn activity is suppressed by hepcidin, an endogenous peptide hormone, which inhibits iron export and promotes endocytosis of Fpn. Hepcidin deficiency leads to hemochromatosis and iron-loading anemia. Previous studies have shown that small peptides that mimic the first few residues of hepcidin, i.e., minihepcidins, are more potent than hepcidin. However, the mechanism of enhanced inhibition by minihepcidins remains unclear. Here, we report the structure of human ferroportin in complex with a minihepcidin, PR73 that mimics the first 9 residues of hepcidin, at 2.7 Å overall resolution. The structure reveals novel interactions that we...
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was la...
Hepcidin is a new peptide hormone secreted by the liver and widely distributed among animals, from f...
The negatively charged Asp325 residue has proved to be essential for iron export by human (HsFPN1) a...
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the...
SummaryThe peptide hormone hepcidin is a key homeostatic regulator of iron metabolism and involved i...
A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole ce...
International audienceFerroportin (SLC40A1) is the only known iron exporter in mammals and is consid...
International audienceGenetic medicine applied to the study of hemochromatosis has identified the sy...
Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1). We demonstrated that hep...
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was la...
The hepcidin-ferroportin axis underlies the pathophysiology of many iron-associated disorders and is...
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was la...
Hepcidin is a new peptide hormone secreted by the liver and widely distributed among animals, from f...
The negatively charged Asp325 residue has proved to be essential for iron export by human (HsFPN1) a...
The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin on the...
SummaryThe peptide hormone hepcidin is a key homeostatic regulator of iron metabolism and involved i...
A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole ce...
International audienceFerroportin (SLC40A1) is the only known iron exporter in mammals and is consid...
International audienceGenetic medicine applied to the study of hemochromatosis has identified the sy...
Hepcidin regulates iron metabolism by down-regulating ferroportin-1 (Fpn1). We demonstrated that hep...
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was la...
The hepcidin-ferroportin axis underlies the pathophysiology of many iron-associated disorders and is...
Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was la...
Hepcidin is a new peptide hormone secreted by the liver and widely distributed among animals, from f...
The negatively charged Asp325 residue has proved to be essential for iron export by human (HsFPN1) a...